| 提要文摘： | A group of eight closely related acyl depsipeptides (ADEPs) as antibiotics hasbeen previously isolated from the fermentation broth of Streptococcus hawaiiensisNRRL 15010 and briefly described as the 'A54556 complex' in a patentl'J. Thesecompounds all contain a proline-rich macrocyclodepsipeptidolactone with adifferentially substituted aromatic usual or unusual amino acid, which isN-acylated by a different specific fatty acid. The solid phase synthesis of theseADEPs is complicated by three factors: (a) the cyclic nature of the peptide, (b) thelactone functionality, and (c) the presence of several non-proteinogenic aminoacids with in vitro activity against staphylococci and streptococci. However, noinformation is available regarding the in vivo potency or mechanism of action ofthese ADEPs. The reported structures of natural product ADEP l ('factor A') andits optimized congeners are shown in Fig. 1. Generally, they have some variationsin some residues and one "unusual" fatty acid. |
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